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KMID : 0359720180360020116
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Journal of the Korean Neurological Association
2018 Volume.36 No. 2 p.116 ~ p.118
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Metronidazole-Induced Encephalopathy with Thiamine Deficiency
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Kim Rae-Young
Lee Deok-Soo
Gwag Byeong-Cheol
Lee Yoon-Kyung
Cheon Sang-Myung
Jeong Jin-Heon
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Abstract
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Metronidazole-induced encephalopathy (MIE) can be caused by excessive dose or prolonged metronidazole administration. The signal abnormalities in the cerebellar dentate nuclei, midbrain, dorsal pons and corpus callosum on magnetic resonance imaging are considered as the characteristic feature of MIE. Although the mechanism of MIE remains to be elucidated, various hypothesis have been proposed including the role of metronidazole as a thiamine antagonist. Here we report a 58-year-old woman with MIE who coincidentally presented with thiamine deficiency.
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KEYWORD
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Metronidazole, Encephalopathy, Thiamine
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